Induction of Oxidative Stress in Kidney

Induction of Oxidative Stress in Kidney

Oxidative stress has a critical role in the pathophysiology of several kidney diseases, and many complications of these diseases are mediated by oxidative stress, oxidative stress-related mediators, and inflammation. Several systemic diseases such as hypertension, diabetes mellitus, and hypercholesterolemia; infection; antibiotics, chemotherapeutics, and radiocontrast agents; and environmental ...

Oxidative Stress – Environmental Induction

The protective effect of rosemary in mitigating oxidative stress induced by Chlorpyrifos in rat kidney

Introduction: Chlorpyrifos is an organophosphorus insecticide that can produce reactive oxygen species, and oxidative stress in the kidney. On the other hand, rosemary extract is an antioxidant playing a protective role against free radicals. Therefore, the aim of this study was to evaluate the oxidative stress in rat kidney due to the exposure to chlorpyrifos and to assess the antioxidant effe...

Induction of Oxidative Stress by Acute Oral Exposure of Cadmium Chloride in Kidney of Adult Rat

Cadmium is a heavy metal, a well recognized environmental pollutant with numerous adverse health effects. Being widely used in industry, cadmium can affect human health through occupational and environmental exposure (Waisberg et al., 2003). The level of cadmium compounds in the environment have progressively increased as a consequence of industrial pollution which can be attributed to electrop...

Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease.

Chronic nephropathy is a recognized complication of sickle cell disease. Using a transgenic sickle mouse, we examined whether oxidative stress occurs in the sickle kidney, the origins and functional significance of such oxidant stress, and the expression of the oxidant-inducible, potentially protective gene, heme oxygenase-1 (HO-1); we also examined the expression of HO-1 in the kidney and in c...